Nicole de Buhr, PhD

Nicole de Buhr, PhD studied from 2006 to 2012 veterinary medicine at University of Veterinary Medicine Hannover. During this time she did several internships in research institutions, as for example at the Federal Research Institute for Animal Health (FLI) Riems in Institute of Infectology and Department of Experimental Animal Facilities and Biorisk Management where she worked with fish cell culture, fish pathogens (e.g. herpesvirus CyHV-1) and Influenza-A-Virus. Furthermore, she worked for 4 month at the Institute for Microbiology on an immunoproteomic approach with Streptococcus suis.

She performed her PhD thesis about “Interaction of Streptococcus suis and neutrophil extracellular traps (NETs)” at the University of Veterinary Medicine Hannover in the Institute for Microbiology. In November 2015 she received her PhD title and in 2016 her PhD thesis was awarded with the Gerhard-Domagk Award for Life Sciences.

Since October 2015 she has been a member of the Infection Biochemistry research group at the Institute of Physiological Chemistry at the University of Veterinary Medicine in Hannover. Her research area of interest is “The function of neutrophil extracellular traps (NETs) in different animal species” with a focus on:

  • NETs in immune-privileged compartments
  • Significance of NETs in autoimmune diseases
  • Infectious diseases and NET formation

In 2017 she worked on a research project in Costa Rica at the Universidad Heredia about NETs in dogs and opossums as a response to Trypanosoma cruzi.

Selected publications:

Baien, S.H.; Langer, M.N.; Heppelmann, M.; von Köckritz-Blickwede, M.*; de Buhr, N.*; Comparison between K3EDTA and Lithium Heparin as anticoagulant to isolate bovine granulocytes from blood. Frontiers Immunology; 9:1-13, doi: 10.3389/fimmu.2018.01570 (*contribute equal)

de Buhr, N.; Bonilla, M. C.; Jimenez-Soto, M.; von Köckritz-Blickwede, M.; Dolz, G.; Extracellular trap formation in response to Trypanosoma cruzi infection in granulocytes isolated from dogs and common opossums, natural reservoir hosts. Frontiers Microbiology, 9:1-12, doi: 10.3389/fmicb.2018.00966

de Buhr, N.; Reuner, F.; Neumann, A.; Stump-Guthier, C.; Tenenbaum, T.; Schroten, H.; Ishikawa, H.; Müller, K.; Beineke, A.; Henning-Pauka, I.; Gutsmann, T.; Valentin-Weigand, P., Baums, C.G. and von Köckritz-Blickwede, M.; Neutrophil extracellular trap formation after transmigration of neutrophils through Streptococcus suis infected human choroid plexus epithelial cell barrier. Cellular Microbiology 19:1-16, doi:10.1111/cmi.12649

de Buhr, N.* and von Köckritz-Blickwede, M.*; How neutrophil extracellular traps (NETs) become visible. Journal of Immunology Research, vol. 2016, Article ID 4604713, 13 pages. DOI:10.1155/2016/4604713 (*contribute equal)